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Toxicity of aluminum using lipid peroxidation product – Malondialdehyde (MDA) concentration in serum, liver and brain homogenates in male Wistar albino rats was investigated in this study. A total of eighteen (18) rats of six (6) each in a group were administered 0.38 and 38 mg/kg body weight aluminum while the control group received 0.2ml normal saline for seven and fourteen days respectively. The results from this study show that MDA concentrations were significantly higher (p<0.05) and non-significantly higher (p>0.05) in 38mg/kg and 0.38mg/kg in serum, liver and brain homogenates after 7 and 14 days of aluminum treatment. However, the MDA concentration was highest in the brain homogenate. The results suggest lipid peroxidation probably due to the generation of free radicals, though need to be investigated further.

Isolated mononuclear leukocytes, when incubated with purified haemoglobin Ao (HbAo), release the pro-inflammatory cytokines interleukin-8 (IL-8) and tumor necrosis factor-? (TNF-?). Thus, inflammation is believed to play a role in preeclampsia. Leukocytes increase due to inflammatory response. There is also increased hemoglobin production in the PE placenta. The hemoglobin may be released into the placenta blood vessel lumen. In addition, Gene and protein profilingstudies have shown increased expression and accumulation of free fetal hemoglobinin the preeclamptic placenta. Predominantly due to oxidative damage to the placentalbarrier, fetal hemoglobin leaks over to the maternal circulation. Oxidative stress in general, and more specifically fetal hemoglobin-inducedoxidative stress, could play a key role in the pathology of preeclampsia seen both in theplacenta and ultimately in the maternal endothelium.

Background: The newly developed herbal Formulation (LIV01-SSA-23), that has a combination of multiple medicinal herbs such as the powders of Solanum nigrum, Holarrhena antidysentrica, Tephrosia purpurea, Andrographis paniculata, Phyllanthus niruri, Tinospora cordifolia, Terminalia chebula, Asteracantha longifolia, Alstonia scholaris, Berberis aristata, Chichorium intybus, Picrorhiza kurroa, was tested for its antioxidant and free radical scavenging activity in vitro. This PHF has been traditionally used by the ayurvedic practioners in India, for the treatment of various liver complications and inflammatory disorders. Methodology: The developed formulation was tested for total reducing power and in vitro antioxidant activity by ABTS assay, Superoxide anion scavenging activity assay and Lipid per-oxidation assay. Conclusion: In conclusion, we strongly suggest that Polyherbal formulation are source of potential antioxidant for radical scavenging. The highly positive correlation of anti?radical scavenging activity and total polyphenolic content in Polyherbal compounds indicates that polyphenols are important components which could be used for the free radical scavenging activity. Further study is needed for isolation and characterization of the active moiety responsible for biological activity and to treat in various stress condition.