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Polyherbal formulations were developed by using five bioactive N-butanol fractionated extracts of Eclipta alba, Picrorhizakurroa(Rhizome), Terminaliachebula (fruits),Piper nigrum (fruits),Nigella sativa(seeds), Tribulusterristris(whole plant) Linn, treatment of liver disorders by exploiting the knowledge of traditional system of medicine and evaluated for hepatoprotective activity using acute liver toxicity models of paracetamol,ccl4, ethanol, isoniazide induced liver damage in rats. Major active fractions were isolated by solvent fractionation and quantified by column chromatographic method. Two polyherbal tablet formulations were developed by the wet granulation method using microcrystalline cellulose, aerosil and other excipients and subjected for physicochemical evaluation to assess physical stability followed by pharmacological screening. The prepared tablets were finally subjected to stability testing to assess its shelf-life. The rats were monitored for change in liver morphology, biochemical parameters for polyherbal tablet formulation at 50 mg/kg and polyherbal tablet formulation at 100 mg/kg. Both formulations showed significant hepatoprotective activity. The histological studies were also support the biochemical parameters. From the results of biochemical analysis and histopathological studies, Biochemical marker showed improved results for polyherbal tablet formulation at 100 mg/kg. Polyherbal tablet formulation contains a potent hepatoprotective agent suggested to be a butanol fraction concentrated in polyherbal formulation which may find clinical application in amelioration of paracetamol, ethanol, ccl4, isoniazide induced liver damage.

Background: The newly developed herbal Formulation (LIV01-SSA-23), that has a combination of multiple medicinal herbs such as the powders of Solanum nigrum, Holarrhena antidysentrica, Tephrosia purpurea, Andrographis paniculata, Phyllanthus niruri, Tinospora cordifolia, Terminalia chebula, Asteracantha longifolia, Alstonia scholaris, Berberis aristata, Chichorium intybus, Picrorhiza kurroa, was tested for its antioxidant and free radical scavenging activity in vitro. This PHF has been traditionally used by the ayurvedic practioners in India, for the treatment of various liver complications and inflammatory disorders. Methodology: The developed formulation was tested for total reducing power and in vitro antioxidant activity by ABTS assay, Superoxide anion scavenging activity assay and Lipid per-oxidation assay. Conclusion: In conclusion, we strongly suggest that Polyherbal formulation are source of potential antioxidant for radical scavenging. The highly positive correlation of anti?radical scavenging activity and total polyphenolic content in Polyherbal compounds indicates that polyphenols are important components which could be used for the free radical scavenging activity. Further study is needed for isolation and characterization of the active moiety responsible for biological activity and to treat in various stress condition.